The patient had been on Amiodarone therapy for several years. These deposits occur in various levels of the cornea. Two months prior to this routine follow up, the patient's primary care doctor made a change in the patient's cardiac medications which included the removal of amiodarone from his medication regimen. Corneal verticillata, also called vortex keratopathy, are one type of corneal deposits. Hydroxychloroquine surfactant deficiency Hair loss lupus plaquenil Lyme biaxin plaquenil Hydroxychloroquine sulfate 200 mg In 1 case related to perhexiline maleate, papilledema appearing concurrently with the vortex keratopathy and considered drug related resulted in significant visual acuity loss that did not completely reverse after withdrawal of the drug. 24 Besides asymptomatic vortex keratopathy, retinal toxicity—including macular and peripheral retina. BACKGROUND Vortex keratopathy, arising as a side effect of several medications, is characterized by golden-brown deposits in the cornea. METHODS A 41-year-old woman treated for sarcoidosis with hydroxychloroquine therapy and suffering from vortex keratopathy was examined by in vivo confocal microscopy. Scans of both corneas were performed. The long-term administration of hydroxychloroquine HCQ sulfate is well known to be associated with AE, such as vortex keratopathy and in particular the often irreversiblenih.gov as convulsion-like syndromes and impaired consciousness. 54 MRI revealed abnormal signal intensity on T2-weighted images in all cases. The opacities branch out from a central whorl, usually across the inferior cornea. Verticillata are readily recognizable by their distinct appearance as fine, golden-brown or gray opacities that are almost always bilateral. Vortex keratopathy hydroxychloroquine Hydroxychloroquine-related retinal toxicity Rheumatology., In vivo confocal microscopy in hydroxychloroquine-induced. Chloroquine lysosome sigma Taking Hydroxychloroquine develop toxicity2 It’s rare for side effects to occur with Plaquenil if the medication is dosed properly Side effects Blurred vision, bull’s eye maculopathy, scotoma, vortex keratopathy, headache, accommodative dysfunction, whitening of eyelashes, phototoxicity3 Early Plaquenil Toxicity Detected without Bull’s Eye Maculopathy. Consciousness Disorder & Vortex Keratopathy Causes & Reasons.. Hydroxychloroquine - Wikipedia. A number of prescription drugs are well known for their potential retinal toxicity, including Plaquenil hydroxychloroquine, Sanofi Aventis, tamoxifen and thioridazine.1 Vortex keratopathy has been linked to use of amiodarone and indomethacin.2 Anti-anxiety medications, such as Prozac fluoxetine, Eli Lilly and Zoloft sertraline, Pfizer. Start studying Ocular Side effects of Oral Medications. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Hydroxychloroquine or Chloroquine? Daily dose over 5 mg/kg/day Renal dysfunction. Vortex keratopathy CHAI-T The aminoquinolones chloroquine and hydroxychloroquine have been widely used in the treatment of SLE. These drugs can cause a reversible, visually insignificant keratopathy cornea verticillata and, more importantly, an irreversible sight-threatening maculopathy. Clinical progression is of loss of the foveal reflex followed by a fine granular appearance of the macula and finally a “bull's eye” maculopathy presenting as a central scotoma.