Chloroquine retinopathy mechanism

Discussion in 'Canada Drug' started by CtacC, 24-Feb-2020.

  1. [email protected] Moderator

    Chloroquine retinopathy mechanism


    One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus.

    Plaquenil toxicity and eyes Plaquenil wonder drug

    Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain. Their mechanism of action is not entirely understood. However, despite their varying therapeutic dosage and toxicity, both drugs have similar clinical indications and side effects. One of their most serious side effects is retinal toxicity, referred to as 4AQ retinopathy or chloroquine retinopathy, which must be screened for in all cases of. Retinopathy, maculopathy, irreversible retinal damage, as well as macular degeneration have been reported. Retinopathy from chloroquine may be dose related. Initial and periodic eye examinations are recommended during prolonged treatment. Chloroquine should be discontinued immediately if there are changes in vision.

    It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress.

    Chloroquine retinopathy mechanism

    Chloroquine Retinopathy Symptoms, Diagnosis and Treatment., Chloroquine and hydroxychloroquine – Knowledge for medical.

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  6. Mechanism of action The precise mechanism by which hydroxychloroquine exhibits activity against Plasmodium is not known. Hydroxychloroquine, like chloroquine, is a weak base and may exert its effect by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme.

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    Disease EntityDiagnosisManagementAdditional ResourcesReferences Side effectsManagementGoalsMechanismPrognosisPathophysiologyToxicityPreventionInteractionsGeneticsPurposeMedical usesAnalysisResearchDiagnosisSecurityResourcesContraindications Apr 02, 2019 Mechanism of Action. Chloroquine is an antimalarial agent. While the drug can inhibit certain enzymes, its effect is believed to result, at least in part, from its interaction with DNA. However, the mechanism of plasmodicidal action of chloroquine is not completely certain. Activity in vitro and in vivo

     
  7. bukasa Guest

    Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. Early Plaquenil Toxicity Detected without Bull’s Eye Maculopathy Hydroxychloroquine toxicity - EyeWiki Will you have Keratopathy band with Plaquenil - eHealthMe
     
  8. Neverius Moderator

    En estudios animales ha producido daño fetal y no hay estudios adecuados en mujeres embarazadas. Hydroxychloroquine Sulfate 200 mg PRECIOS DE Plaquenil – Información Comercial Farmacias del Ahorro Plaquenil 200 mg oral 20 tabletas.
     
  9. rent007 New Member

    Inflammatory Osteoarthritis And Plaquenil Nov 28, 2010 Plaquenil reduces inflammation in many Rheumatic disorders, the mode of action is pretty complicated though so I shan't bore you with all the details, but basically it prevents your dendritic cells these are messengers for your immune system, if you will from interacting with your T-Cells a special type of white blood cell which through a convoluted and boring process, causes inflammation when an infection is found, and these basically malfunction with inflammatory disorders.

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