Chloroquine half life

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  1. kabanello Guest

    Chloroquine half life


    In addition, the impact of the patient’s physiopathological status and ethnic origin on chloroquine pharmacokinetics is discussed. In humans, chloroquine concentrations decline multiexponentially. The drug is extensively distributed, with a volume of distribution of 200 to 800 L/kg when calculated from plasma concentrations and 200 L/kg when estimated from whole blood data (concentrations being 5 to 10 times higher).

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    Half-life time of this drug is approximately 18 hours in vivo due to the degradation by the liver, but the stability of chloroquine in vitro experiments is expected to be longer. Hence, unbound plasma concentrations are higher for R−-chloroquine. Following separate administration of the individual enantiomers, R−-chloroquine reached higher and more sustained blood concentrations. The shorter half-life of S+-chloroquine appears secondary to its faster clearance. In order to determine the pharmacokinetic disposition of chloroquine CQ and its active metabolite, desethylchloroquine DECQ, when administered as intermittent presumptive treatment in pregnancy IPTp for malaria, 30 Papua New Guinean women in the second or third trimester of pregnancy and 30 age-matched nonpregnant women were administered three daily doses of 450 mg CQ 8.5 mg/kg of body.

    Following administration chloroquine is rapidly dealkylated via cytochrome P450 enzymes (CYP) into the pharmacologically active desethylchloroquine and bisdesethylchloroquine. Chloroquine is 60% bound to plasma proteins and equally cleared by the kidney and liver.

    Chloroquine half life

    Pharmacokinetics, Pharmacodynamics, and Allometric Scaling., Clinical Pharmacokinetics and Metabolism of Chloroquine SpringerLink

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  4. Prolonged half life of several weeks 50% of chloroquine is excreted unchanged; Resuscitation Coma Prompt intubation and ventilation, if acidaemia exists, give sodium bicarbonate 1 – 2 mmol/Kg IV to prevent further toxicity during intubation. End goals should be a narrow QRS 100ms and a pH 7.45

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    A metabolite of chloroquine – hydroxychloroquine – has a long half-life 32–56 days in blood and a large volume of distribution 580–815 L/kg. The therapeutic, toxic and lethal ranges are usually considered to be 0.03 to 15 mg/l, 3.0 to 26 mg/l and 20 to 104 mg/l, respectively. In contrast to quinine which has a relatively limited apparent volume of distribution approximately 2.51/kg in healthy adults and short elimination half-life 11 hours in healthy subjects, 16 hours in cerebral malaria, chloroquine has an enormous total apparent volume of distribution 100–10001/kg and a terminal elimination half-life of. The elimination half-life from milk averaged 8.8 days.9 Ten women who were taking oral chloroquine 300 mg/week of chloroquine during pregnancy were changed to a dose of 100 mg/day for the last 10 days of pregnancy and first 10 days postpartum.

     
  5. fmcoder Well-Known Member

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Aralen - definition of Aralen by The Free Dictionary Chloroquine C18H26ClN3 - PubChem Aralen - Drugs Home Page
     
  6. Paca Moderator

    The management of rheumatic diseases in pregnancy Pregnancy can create a challenge for physicians caring for women with rheumatic diseases. For many women with rheumatoid arthritis RA, pregnancy can provide a reprieve from long-term joint pain and inflammation, but others will not experience remission and will continue to need medication.

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  7. miss713 Guest

    Hydroxychloroquine Oral Tablet 200Mg Drug Medication. Hydroxychloroquine Oral tablet 200mg Drug Medication Dosage information. Learn about the reported side effects, related class drugs, and how these medications will affect your daily lifestyle. Visit for more details.

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