At first it seemed like it helped now I feel the same as before I started taking the medicine other than the fact that none of my clothes fit and there is a lot more of me to carry around. Anyone know if I quit taking it if the weight will fall back off I started Hydroxychloroquine 2 weeks ago. One week in and I thought this may just work, except for the ‘extra itchiness’ I seemed to get every night. Chloroquine mechanism of action autophagy Para que es hydroxychloroquine 200 mg Have you followed up with your dr about the swelling if not you might want to. I know it takes a couple of days for the preisone to get in your system. Give the doc a call and see what they say; they might not be able to get you an appt but they can tell you if it is something you should be concerned about or not. Hydroxychloroquine is used to treat malaria. It is also used to prevent malaria infection in areas or regions where it is known that other medicines eg, chloroquine may not work. Hydroxychloroquine belongs to a group of medicines known as antimalarials. It works by preventing or treating malaria. Mar 24, 2011 Had headaches with the plaquenil so went to the sulfar and predisone. Sulfar was a waste of time and since I had a little help from the plaquenil he switched me back to that with pain meds for the headaches and body. Recently i went back for app. and plaquenil had stopped doing anything so he added the methotrexate to it. I did not want to take it. I was prescribed this drug to ease my ra disease, I was taking 400mg per day which was to last for 3 months then reduced to 200mg. Right before I hit the two week mark, I woke up with my heart racing and continued feeling my heart flutter all day and I just felt week and tired. After msging Rheum, decided to stop taking meds to see how I feel and continue with the AIP to handle symptoms and try to work at ‘healing from inside out! Time will tell and I’m eager to see how much the AIP is helping once odd meds. Hydroxychloroquine not working Does anyone take methotrexate and hydroxychloroquine., Hydroxychloroquine Oral Route Description and Brand. Hydroxychloroquine for dermatomyositis Urgent care Urgent care centers can be faster and cheaper for situations that are not life threatening. Health A to Z Back Health A to Z. Learn about conditions. Signs Your RA Treatment Isn't Working. What next if plaquenil doesn't work?. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Hydroxychloroquine or chloroquine tablets should be taken with or after food to reduce stomach upset. This drug does not work immediately. It may be weeks to months before you notice any benefit. Thus it is important that you take your medication regularly, otherwise, you may not receive any benefit at all. Re Plaquenil not working anymore Lizzy, I took 400mg 200 twice a day for 16-18 months forget exact duration, then was reduced to 200 mg daily. But right from the start, I also needed NSAID's for pain. Hydroxychloroquine along with 30 mg of Prednisone worked for me within 3 months and did a great job. However I had a side reaction- hallucination, so I came off the drug. Plaquenil did not work as well for me,it took about 10 weeks before I saw some effect but again I had a reaction- my fatigue got even worse and I could not stay awake.