Given the urgent need for ZIKV prophylaxis and treatment, repurposing of approved drugs appears to be a viable and immediate solution. We demonstrate that the common anti-malaria drug chloroquine (CQ) extends the lifespan of ZIKV-infected interferon signalling-deficient AG129 mice. What happens if you double doses of plaquenil What is hydroxychloroquine Plaquenil and calcium levels Order aralen phosphate Accordingly, the induction of autophagy by rapamycin promoted ZIKV load in both fNSCs and HeLa cells, whereas the inhibition of autophagy by 3-MA or chloroquine impaired ZIKV load Figures 1J, S2J, and S2K. These results indicate that ZIKV infection induces autophagy in fNSCs, which in turn leads to increased ZIKV replication and viral load. Terskikh is co-senior author of a new study that examined the effect of chloroquine in human brain organoids and pregnant mice infected with the virus, and found the drug markedly reduced the amount of Zika virus in maternal blood and neural progenitor cells in the fetal brain. Here we show that chloroquine exhibits antiviral activity against ZIKV in VERO, human brain microvascular endothelial, and neural stem cells. We demonstrated in vitro that chloroquine reduces the number of ZIKV-infected cells, virus production and cell death promoted by ZIKV infection without cytotoxic effects. Here, we show that interferon signalling-competent SJL mice support chronic ZIKV infection. However, the severity of ZIKV infection in these mice precludes the study of foetal (vertical) viral transmission. Chloroquine zika cell Anti-malaria drug shows promise as Zika virus treatment., Chloroquine reduces transmission of Zika virus from mother. What heart problems are associated with plaquenil Dec 11, 2017 Treating Zika Virus with the Antimalarial Chloroquine Leave a reply When the Zika virus spread into the United States last year, the main concern was the potential damage it could cause to the fetus in pregnant women. Treating Zika with the Antimalarial Chloroquine - Woodland.. Chloroquine inhibits Zika Virus infection in different.. Trump Suggests Anti-Malarial Drug Chloroquine Is an.. Nov 17, 2017 Chloroquine, an Endocytosis Blocking Agent, Inhibits Zika Virus Infection in Different Cell Models. Viruses 8, https//doi.org/10.3390/v8120322 2016. 13. Cao, B. Parnell, L. A. Diamond, M. S. &. Nov 20, 2017 Terskikh is co-senior author of a new study that examined the effect of chloroquine in human brain organoids and pregnant mice infected with the virus, and found the drug markedly reduced the amount of Zika virus in maternal blood and neural progenitor cells in the fetal brain. One of the major challenges of the current Zika virus ZIKV epidemic is to prevent congenital foetal abnormalities, including microcephaly, following ZIKV infection of pregnant women. Given the urgent need for ZIKV prophylaxis and treatment, repurposing of approved drugs appears to be a viable and immediate solution.