B, Brown pigmentation on the legs in another patient who had systemic lupus erythematosus associated with diffuse discoid lupus. The skin biopsy was performed on the brown area distant from discoid lesions. Hydroxychloroquine lyme treatment Ra medication plaquenil Plaquenil eye effects I've started to get really tender shins and bruising for no reason on my legs. I've seen my gp and they are miffed and have done some blood tests. I have alot of fatigue and my legs feel heavy, im on plaquenil and nifidipine for raynauds. has anyone else had this? Erythema nodosum is a type of skin inflammation that is located in a part of the fatty layer of skin. Erythema nodosum results in reddish, painful, tender lumps most commonly located in the front of the legs below the knees. The tender lumps, or nodules, of erythema nodosum range in size from a dime to a quarter. Apr 25, 2012 I have Lupus and I too take Plaquenil, 200mg. I do bruise very easy but not sure if it is the Plaquenil because I take other meds also. I constantly look and see bruising all the time. But the other symptoms you are describing I have not had a problem with. I would talk to me doctor right away because they don't sound right. B, Presence of iron in the same areas of the dermis (Perls staining, original magnification ×100). Pub Med Google Scholar Crossref Morrison LK, Nordlund JJ, Heffernan MP. Pub Med Google Scholar Costedoat-Chalumeau N, Galicier L, Aumaître O, et al; Group PLUS. Google Scholar Costedoat-Chalumeau N, Amoura Z, Hulot JS, et al. Pub Med Google Scholar Crossref Costedoat-Chalumeau N, Leroux G, Piette J-C, Amoura Z. A, Interstitial and perivascular brown pigmented granules in the dermis (hematoxylin-eosin-safran staining, original magnification ×100). Bruising on shin from plaquenil Reasons You’re Bruising Easily, Erythema Nodosum Symptoms, Causes, Diagnosis, and Treatment Plaquenil sjogren's pregnancyDoes plaquenil affect cgrp inhibitorsPlaquenil pyroderma Plaquenil, systemic lupus erythematosus, bruising, skin. I have been taking the drug for almost two year for Sjogrens syndrome/lupus and recently I have noticed unexplainable brusing on my back and thighs. Has anyone taking Plaquenil ever experienced bruising.. Bruising and plaquenil - Lupus - Inspire. Plaquenil Oral Uses, Side Effects, Interactions, Pictures.. Hydroxychloroquine Plaquenil stimulates the pigment producing cells in the skin called melanocytes. As a result, there is both hemosiderin iron and melanin accumulation in the dermis. The exact reasons why this phenomenon happens is not clear. However, trauma and bruising may faciliate the developement of pigmentation. Unusual bleeding or bruising upper right abdominal or stomach pain watery or bloody diarrhea weight gain or loss yellow eyes or skin Rare. Area rash blistering, peeling, or loosening of the skin bloody or black, tarry stools clay-colored stools cold, clammy skin continuing vomiting cough cracks in the skin difficulty with swallowing Oct 22, 2019 The risk may also be higher with some doses of Plaquenil hydroxychloroquine, if you use Plaquenil hydroxychloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. Call your doctor right away if you have any eyesight changes like blurred or foggy eyesight, trouble focusing or reading, or trouble seeing in dim light.