Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil facial swelling Do you have to wean off hydroxychloroquine Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. Have any of you who have taken Plaquenil developed Hemolytic Anemia? I just got back from the NIH in which I participate in an MGUS Natural History Study.my preliminary bloodwork indicated high Reticulocyte Percentage for the first time. Hello Potslupus, I already had Anaemia before taking plaquenil but anaemia is one of the side affects of plaquenil if it occured after taking the med but Lupus also can cause it.you really need to know which one as caused it. Here are the side affects of plaquenil and someone will answer in due course. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Will plaquenil help anemia Common and Rare Side Effects for Plaquenil Oral, Plaquenil and Hemolytic Anemia - Sjogren's World Maximum dose of plaquenil Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Hydroxychloroquine Plaquenil. Plaquenil and Anemia - General Discussion - Life With Lupus. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.. Hemolytic Anemia is #227 concern in Plaquenil discussions. Plaquenil is an arthritis medication and an anti infectious agent. Uses Plaquenil is prescribed for Lupus, RA, Sjogren's Syndrome and Joint Pain and is mostly mentioned together with these indications. I currently take B12 sublingual and iron supplements and it seems to be helping some. But, what I found most helpful for me and my fatigue as related to sjogrens anyway, is taking plaquenil for almost five months now - I think it is starting to kick in and help some. I wish you the best and sending positive thoughts and prayers your way. Overall, most people who have any noticeable side effects from hydroxychloroquine experience diarrhea or nausea. These usually get better after the person adjusts to the medication, and taking the drug with food can help, as well. Additionally, some people experience anemia and vision changes or even vision loss, but this is quite rare.