One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Chloroquine drug info How to take chloroquine phosphate 500 mg Plaquenil facial swelling Overdose symptoms may include Headache. Drowsiness. Vision changes. Slow heart rate. Chest pain or heavy feeling. Pain spreading to the arm or shoulder. Nausea. Sweating. Seizure. Shallow breathing. Breathing that stops. This condition does not cause symptoms and is reversible with cessation of the medication. The finding of corneal verticillata bares no correlation with retinal toxicity and is not an indication to stop the medication 1. The hallmark of hydroxychloroquine toxicity is bilateral pigmentary retinopathy 1. With Plaquenil related toxicity, the pigment in the macula can change and alter vision by producing blurring and distortion of objects. These changes, if they are going to occur, happen slowly over a long period of time. Your eye care provider can examine the macula and detect subtle changes before you begin to notice any symptoms of problems. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Plaquenil toxicity symptoms What are the symptoms of Plaquenil toxicity?, Hydroxychloroquine Plaquenil Toxicity and. Plaquenil and liver diseaseHydroxychloroquine 200 mg t End stage hydroxychloroquine toxicity leads to widespread RPE and retinal atrophy with a loss of central vision, peripheral vision, and night vision. Hydroxychloroquine Plaquenil Toxicity and Recommendations.. Conditions Plaquenil-related Eye Problems Eugene Eye Care. Plaquenil Toxicity Screening - Retina Group of New York. Plaquenil is a slow-acting drug, meaning that it can take up to 6 months to experience the full benefits of this medication, but it is possible for symptoms to improve in as few as 1 or 2 months. Plaquenil and other antimalarials are the key to controlling lupus long-term, and some lupus patients may be on Plaquenil for the rest of their lives. Plaquenil toxicity isn’t even in the top 10, or the top 100” if you’re looking at incidence, he said. “It’s a pretty rare thing.” Nevertheless, he urged doctors to master the Academy’s new guidelines, because the effects from chloroquine and hydroxychloroquine, when they do occur, are severe and often irreversible. Mar 15, 2019 Other reported visual symptoms include the following Dimness. Flickering or flashing lights of yellow. Green or red haloes. Cycloplegia. Amblyopia. Diplopia. Blindness. Photophobia. Oculogyric crisis.