Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Plaquenil (hydroxychloroquine) with all of your drugs and health problems. Hydroxychloroquine interactions Plaquenil crest syndrome Plaquenil drug category Get emergency medical help if you have signs of an allergic reaction to Plaquenil hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Taking Plaquenil long-term or at high doses may cause irreversible damage to the retina of your eye. Stop taking Plaquenil and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your eyes. Call your doctor at once if you have Today, Plaquenil and other antimalarials are also used to treat and help prevent symptoms caused by certain autoimmune diseases such as rheumatoid arthritis RA, systemic lupus erythematosus, and discoid lupus, even though these diseases are not caused by malaria parasites. Has anyone else had an allergic reaction to Plaquenil? I broke out in hives, all over my body and in my mouth! I was told it was a mid-level reaction to the drug and to stop taking it immediately. I was diagnosed by a very expensive series of blood tests with UCTD, mild Lupus and mild Sjogren’s Syndrome. For all uses of Plaquenil (hydroxychloroquine): WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor. Allergic to plaquenil what else can i take Plaquenil when allergic to sulfa? Lupus Forums at The Lupus., Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus Omeprazole and plaquenil The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is. Plaquenil Oral Interactions with Other Medication. Allergy to Plaquenil - Lupus - Inspire. Allergic reaction to Plaquenil Lupus Forums at The Lupus.. I can say, however, that I have not had any cross allergic reaction to other drugs sometimes associated with sulfa allergies. Whether you try Plaquenil or not is ultimately up to you and your doctor, but a lot will depend on the type and severity of reactions that you've had. Rashes are certainly a lot less severe than respiratory reactions. Mar 25, 2015 I can take brand name Plaquenil the first few weeks cause stomach upset, but if I take the generic - I get a rash, sore throat and it's hard to swallow. Exactly what I get when I took a sulfa drug when I was a child. The generic probably contains sulfa. Also generic drugs can contain a smaller or larger amount of the prescribed ingredients. I am sorry to hear you can't take plaquenil, it's a great med and I can't go without it. I have heard toxicity is very rare and usually only happens if you've been on plaq for many many years 20+ or take it in high doses, more than the standard 400 mg.