It seems as though it has helped the first two symptoms, but I have horrible constipation. Lots of people experience some GI issues when starting Plaquenil, but they usually subside after a short time. I have tried everything- I exercise every day, drink a ton of water, eat fiber like it’s going out of style, follow a gluten-free diet, take stool softeners after every meal and Miralax before bed at night. Did you start Plaquenil when you rec'd your diagnosis and did the constipation begin at the same time? Increase in malaria deaths after chloroquine failure Hydroxychloroquine diagnostic studies routinely Hydroxychloroquine cousins Our Plaquenil hydroxychloroquine Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about. I have been recently diagnosed with Lupus about 4 months ago and have started plaquenil with the hope it would relieve my symptoms no energy, achy body and severe hair loss. It seems as though it has helped the first two symptoms, but I have horrible constipation. I have tried everything- I exercise every day, drink a ton of water, eat fiber like it’s going out of style, follow a gluten. I have intermittent problems with constipation and take Miralax at times - and feel that it sometimes causes bloating. I have really bad cramping, gas and it looks like I’m 7 months pregnant at times! I think it might be possible that the constipation could have something to do with the Lupus, as it can affect the GI tract also. Bad side effects of hydroxychloroquine Hydroxychloroquine MedlinePlus Drug Information, Hydroxychloroquine Oral Route Side Effects - Mayo Clinic Hydroxychloroquine cause hair lossCan plaquenil stop workingChloroquine phosphate and coralsHydroxychloroquine dose medscapeRheumatoid arthirtis methrotrexate therapy hydroxychloroquine monotherapy I started Plaquenil in Feb. I'm anti meds but the time came to try improve quality of my life. The side effects in the 1st week were amplified fatigue & nausea for a good month. I kept taking them & now I don't have any side effects. My energy much better, no more daytime napping needed optition side the retina toxification is very rare. How good is Hydroxychloroquine, and any side effe.. Bad Side Effects of Plaquenil -. Hydroxychloroquine Oral Uses, Side Effects, Interactions.. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. The side effect that is of greatest concern is retinal toxicity. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. My question Do you feel like you've gained weight on Plaquenil ie without Prednisone? The Plaquenil drug side effects list weight loss, but some people have reported weight gain instead. What's happened with you? My rheumy wants me to come down and then off my Plaquenil, but I've been resisting simply because I'm afraid to.