Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Hydroxychloroquine sulfate 200 tabs Plaquenil renal dosing If you are taking hydroxychloroquine for symptoms of rheumatoid arthritis, your symptoms should improve within 6 months. If your rheumatoid arthritis symptoms do not improve, or if they worsen, stop taking the drug and call your doctor. Once you and your doctor are sure the drug works for you. Serious side effects and their symptoms can include the following blurred vision or other vision changes. ringing in your ears or hearing loss. angioedema, or rapid swelling of your skin. hives. mild or severe bronchospasm that causes trouble breathing. sore throat. unusual bleeding or bruising. If the plaquenil is helping and they say you need it, I'd take it - the side effects will go away. I've not had experience with sulfasalazine - but from what I've read, the side effects of that med are about the same as those of plaquenil. BTW - sulfasalazine is an anti-inflammatory. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Taking hydroxychloroquine and sulfasalazine together side effects Hydroxychloroquine Side-effects, uses, time to work, Hydroxychloroquine Side Effects, Dosage, Uses, and More Hydroxychloroquine not working Some side effects that are sulfasalazine might not require any medical attention. These negative effects might evaporate as the body gets used to the medication. Your health care professional might have the ability to assist you to reduce or prevent these negative effects, however do check with them should you be worried about them, or if the. Sulfasalazine 500 mg Tablets Side Effects. Plaquenil and sulfasalazine - Autoimmune Disorders - MedHelp. Hydroxychloroquine Reviews Everyday Health. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about. I take sulphasalazine and hydroxychloroquine in combination with methotrexate, They sometimes give me a slightly dodgy tummy, but nothing unbearable if it gets too problematic I miss 2 or 3 doses and it soon settles again. The key for me is to take it after a meal so that there's food in my tummy which helps with the side effects. Taking the medication for the full six months can help you make a decision about continuing it. Does Hydroxychloroquine Have Side Effects? Like all medications, there is the risk of side effects. Fortunately, the problems seen by people taking this medication are usually very mild. Serious side effects are rare.