While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners. "I started the hydroxychloroquine medication a week ago and within the first day or two noticed a big difference in my pain and fatigue with major improvement SLE. Plaquenil for rheumatoid arthritis pain Hydroxychloroquine drug guide Chloroquine drug action Plaquenil is a DMARD which has been prescribed for years to treat rheumatoid arthritis, lupus, juvenile rheumatoid arthritis, and other autoimmune diseases. When the first biologic DMARD received FDA-approval in 1998, and as other biologics followed in subsequent years, it appeared as though Plaquenil would become less prescribed. Plaquenil is very effective for the symptoms of achiness and fatigue. However, there might be a price to pay in terms of retinal toxicity especially after taking it for as long as you have. Given that the alopecia had developed while you were on the plaquenil, it's not clear that going back on it will help that symptom much. Lupus and Plaquenil research. While Plaquenil was not created with the explicit purpose of helping people minimize the disease activity of lupus, a number of clinical trials have been conducted to examine the clinical impact of the medication. It can decrease the pain and swelling of arthritis. Hydroxychloroquine (Plaquenil) is considered a disease-modifying anti-rheumatic drug (DMARD). What if plaquenil doesn't work for lupus Plaquenil - does it take long time to work? - Lupus - Inspire, PLAQUENIL To Take or Not To Take?" Lupus Community. Hydroxychloroquine site mayoclinic.orgPlaquenil cardiac side effectsPlaquenil calcium Some medicines can slow down your lupus. Doctors call these DMARDs. This stands for Disease-Modifying Anti-Rheumatic Drugs. Hydroxychloroquine is a DMARD. The brand name is Plaquenil. What does Plaquenil do? Plaquenil relieves pain and swelling and prevents damage to joints. How long does Plaquenil take to work? Plaquenil works very slowly. Lupus Medicines Hydroxychloroquine - Brigham and Women's.. Plaquenil Hydroxychloroquine for Lupus - LupusCorner. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Oct 22, 2009 There are pros and cons for all of them and it's a matter of finding one that suits and one that doesn't give you any intolerable side effects. Make sure you take them on a full stomach. Your doc would help you work out which one might be best for you based on your individual circumstances. Good luck! Plaquenil takes quite a long time to get to its peak effectiveness depending on what you read, anywhere from 3 months to a year. Unless you are having significant side effects, try to give it at least 6 months before you decide it doesn't work for you. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis or juvenile idiopathic arthritis and other autoimmune diseases. It is not clear why hydroxychloroquine is effective at treating autoimmune diseases.