It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine mechanism of action drunkbank Effect of chloroquine injection Oct 29, 2018 CHICAGO — Hydroxychloroquine has many indications, including systemic lupus erythematosus. In this setting, it has been shown to reduce flares, prevent organ damage, reduce cardiovascular risks. Apr 10, 2019 Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of hydroxychloroquine can be fatal, especially in children. Plaquenil overdose must be treated. Oct 30, 2019 Risk is most accurately assessed on the basis of duration of use relative to daily dose/body weight Marmor AAO 2016; Melles 2014. Based on these risks, the American Academy of Ophthalmology AAO recommends not exceeding a daily hydroxychloroquine dosage of 5 mg/kg using actual body weight in most patients. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis (or juvenile idiopathic arthritis) and other autoimmune diseases. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Plaquenil pediatric dose for sle Systemic Lupus Erythematosus in Children and Adolescents, Plaquenil Uses, Dosage & Side Effects - User reviews of plaquenilAralen drug interactions Children—Use and dose must be determined by your doctor. For treatment of lupus Adults—200 to 400 milligrams mg taken as a single dose or in two divided doses once a day. Hydroxychloroquine Oral Route Proper Use - Mayo Clinic. Hydroxychloroquine Professional Patient Advice -. UpToDate. Systemic Lupus Erythematosus. 400 mg 310 mg base PO once or twice daily; maintenance 200-400 mg 155-310 mg base PO daily. With prolonged therapy, obtain CBCs periodically. Porphyria Cutanea Tarda Off-label 100-200 mg 77.5-155 mg base PO 2-3 times/wk. Administration. Take with food or milk INTRODUCTION Hydroxychloroquine HCQ is an alkalinizing lysosomatropic drug that accumulates in lysosomes where it inhibits some important functions by increasing the pH. HCQ has proved to be effective in a number of autoimmune diseases including systemic lupus erythematosus SLE. The dosage and length of treatment are based on your medical condition and response to therapy. In children, dosage is also based on weight. For malaria prevention, take this medication by mouth once a week on the same day of the week, or as directed by your doctor. Mark a calendar to help you remember.