It’s also referred to as knee instability or weak knees. While it’s often accompanied by pain, this isn’t always the case. Long term plaquenil therapy Plaquenil keratopathy Plaquenil and Weakness - from FDA reports Summary Weakness is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months, also take medication Enbrel, and have Osteoporosis. PLAQUENIL has been shown to cause severe hypoglycemia including loss of consciousness that could be life threatening in patients treated with and without antidiabetic medications. Patients treated with PLAQUENIL should be warned about the risk of hypoglycemia and the associated clinical signs and symptoms. Nov 28, 2010 Plaquenil reduces inflammation in many Rheumatic disorders, the mode of action is pretty complicated though so I shan't bore you with all the details, but basically it prevents your dendritic cells these are messengers for your immune system, if you will from interacting with your T-Cells a special type of white blood cell which through a convoluted and boring process, causes inflammation. However, if it keeps happening, it could be a sign of something else. If it’s only happened once or twice, you may have just stumbled. Plaquenil knee weakness How Lupus Affects the Muscles, Tendons and Joints Lupus., Plaquenil Hydroxychloroquine Sulfate - Sanofi Is chloroquine injection safe in early pregnancy Side effects include irritability, headache, weakness, hair lightening or loss, stomach upset, nausea, dizziness, muscle pain, rash and itching. Rarely, hydroxychloroquine can affect the bone marrow leading to reduced white blood cells leukopenia or platelets thrombocytopenia and abnormal red blood cells anemia. Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria. Inflammatory Osteoarthritis And Plaquenil. Hydroxychloroquine Plaquenil. Plaquenil and Knee joint replacement by duration, gender and age - a study of FDA data Summary Knee joint replacement is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 10+ years, also take medication Enbrel, and have Pain. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Find information about common, infrequent and rare side effects of Plaquenil Oral.