Mechanism of resistance to chloroquine

Discussion in 'Health Canada Drug Database' started by cc6600, 18-Mar-2020.

  1. Totos XenForo Moderator

    Mechanism of resistance to chloroquine


    Resistance to currently available antimalarial drugs has been confirmed in only two of the four human malaria parasite species, first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted.

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    The major action of chloroquine is to inhibit the formation of hemozoin Hz from the heme released by the digestion of hemoglobin Hb. The free heme then lyses membranes and leads to parasite death. Chloroquine resistance is due to a decreased accumulation of chloroquine in the food vacuole. Efflux of chloroquine from Plasmodium falciparum mechanism of chloroquine resistance Science Chloroquine-resistant Plasmodium falciparum accumulate significantly less chloroquine than. Mechanism of Action. Chloroquine is an antimalarial agent. While the drug can inhibit certain enzymes, its effect is believed to result, at least in part, from its interaction with DNA. However, the mechanism of plasmodicidal action of chloroquine is not completely certain. Activity in vitro and in vivo

    Although resistance to these drugs tends to be much less widespread geographically, in some areas of the world, the impact of multi-drug resistant malaria can be extensive. Has also developed resistance to nearly all of the other currently available antimalarial drugs, such as sulfadoxine/pyrimethamine, mefloquine, halofantrine, and quinine.

    Mechanism of resistance to chloroquine

    Medicines for the Prevention of Malaria While Traveling., Efflux of chloroquine from Plasmodium falciparum mechanism.

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  5. The spread of chloroquine resistance poses a serious challenge to find strategies to treat malaria. an understanding of the molecular mechanisms involved in chloroquine resistance can lead to.

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    ChloroquineResistance In Plasmodium Falciparum. With cholorquine there is emergence of resistance, which has limited its use. Primarily highly effective against febrile illness, relief is quickly achieved within 24 hours. It is easily available, well tolerated and cost effective but now uses are declining because of resistance. 1. High-grade drug resistance of P. vivax has been documented from the Island of Papua both Indonesian and Papua New Guinea and across the Indonesia archipelago, Thailand, Myanmar, Horn of Africa, and Brazil. 96,101 The mechanism of resistance and genetic basis of chloroquine resistance in P. vivax appears to be different from that underlying. Resistance to chloroquine of malaria strains is known to be associated with a parasite protein named PfCRT, the mutated form of which is able to reduce chloroquine accumulation in the digestive vacuole of the pathogen. Whether the protein mediates extrusion.

     
  6. abustaips User

    Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. The Effects of Caffiene on the Lupus Body by Margaret Romero, NP Plaquenil - Uses, Side Effects, Interactions - How to Drink Coffee
     
  7. vbnm070 Moderator

    Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus. Retinal damage – There is a small chance that retinal damage will occur while taking hydroxychloroquine Plaquenil or chloroquine Aralen. For this reason, you should see your ophthalmologist at least once per year so that she/he may check for retinal deposits.

    Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus
     
  8. 21121984 New Member

    Plaquenil and hairloss - HealthBoards Plaquenil will eventually help your hair loss, but that will be a very slow process over a long period of time since plaquenil builds up in your body pretty slowly. And you should keep your head a scalp protected from the sun as VeeJ said.

    I have been prescribed hydroxychloroquine to reduce my hair loss?