It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Plaquenil drug class Methotrexate and folic acid and plaquenil What Is Plaquenil? Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil is available in generic form. Increased IgG4 concentration at the time of presentation, the level of serum IgG4 appeared to be a reliable measure of disease activity. IgG4-RD is an idiopathic, multiorgan inflammatory disease in which diverse organ manifestations are linked by characteristic histopathologic and immunohistochemical features. Treatment with RTX led to prompt IgG4 immunoglobulin G4-related disease IgG4-RD is a systemic fibroinflammatory disease with protean manifestations involving virtually any organ in the body. Hallmarks of IgG4-related disease are lymphoplasmacytic tissue infiltration, fibrosis often in storiform pattern, obliterative phlebitis, and elevated serum IgG4 concentration. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Plaquenil for treatment of igg4 related disease Hydroxychloroquine Plaquenil, Rituximab for the Treatment of IgG4-Related Disease Hydroxychloroquine sulfate 200 mg priceChloroquine phosphate and coral IgG4-related systemic disease IgG4-RSD links a number of inflammatory disorders that previously were considered unrelated. Various clinical manifestations of the condition can cause fibrosis the formation of excessive connective tissue in a growing list of organs and tissues. IgG4-Related Systemic Disease Program. An Overlapping Case of IgG4-Related Disease and Systemic.. How to diagnose IgG4-related disease. Introduction. IgG4‐related disease IgG4‐RD is an immune‐mediated fibroinflammatory condition that can affect multiple organs and lead to tumefactive, tissue‐destructive lesions and organ failure 1the last decade, the disease has become recognized as a unified systemic disorder that links many individual organ conditions once considered to be unrelated 2, 3. Continuous treatment with glucocorticoids for years, even at low doses, is associated with treatment‐related morbidity, particularly in a disease such as IgG4‐RD that often targets the pancreas and affects a patient population that is middle‐aged to elderly 39. Most people with IgG4-related disease are constitutionally well. The IgG4-related disease may be diagnosed as an incidental finding when someone undergoes a routine radiological or surgical investigation. 60–90% of people with IgG4-related disease have multiple organ involvement.