One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Chloroquine cost canada Allergic reaction to plaquenil Plaquenil recent findings sandoz brand Sep 15, 2014 Hydroxychloroquine sulfate HCQ, Plaquenil is an analogue of chloroquine CQ, an antimalarial agent, used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune disorders. Its use has been associated with severe retinal toxicity, requiring a discontinuation of therapy. Hydroxychloroquine should be discontinued if ocular toxicity is suspected and patient should be closely observed given that retinal changes and visual disturbances may progress even after cessation of therapy. Hepatic disease or alcoholism Hydroxychloroquine is still a safe and beneficial drug for use in rheumatic diseases. Retinal toxicity is unpredictable and can occur even at relatively low doses of hydroxychloroquine. There are new screening modalities for early detection of asymptomatic hydroxychloroquine ocular toxicity. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Hydroxychloroquine cornea Plaquenil Side Effects on Your Eyes and Vision, Plaquenil hydroxychloroquine sulfate dosing, indications. Chloroquine and digoxinIn regards to malaria what is chloroquine resistanceChloroquine ingredientsHydroxychloroquine for vascular diseaseChloroquine cells Ocular manifestations of hydroxychloroquine include corneal verticillata and retinal toxicity. Verticillata are cornea deposits of salts within the corneal epithelium. This condition does not cause symptoms and is reversible with cessation of the medication. Hydroxychloroquine Plaquenil Toxicity and Recommendations.. Hydroxychloroquine-related retinal toxicity Rheumatology.. Chloroquine And Hydroxychloroquine Toxicity - StatPearls.. Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. At the initiation of treatment with hydroxychloroquine, the prescribing physician should refer the patient to an ophthalmologist. During the initial examination, it is recommended that the patient receive 1 a thorough ocular examination documenting any preexisting conditions, 2 a Humphrey visual field central 10-2 white-on-white pattern, and Chloroquine and hydroxychloroquine belong to the quinolone family. They are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity, although their therapeutic and toxic doses differ.