Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Hydroxychloroquine pediatric lupus Pill plaquenil generic dog bone shapped Tussin dm and hydroxychloroquine interaction Methotrexate sulfasalazine and hydroxychloroquine I have been on Plaquenil for about 15 years without apparent side effects until this year. But this year I have developed severe swelling of the face and red rash on the upper half of my face. This also includes very difficult itching in odd places on my body, my eyebrows and eyelashes, my earlobes, my lower legs and lower arms, my scalp and. Serious Side Effects of Plaquenil. If you are taking Plaquenil long-term, such as for an autoimmune condition, your doctor should regularly check you for potential serious side effects. Knee joint replacement is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 10+ years, also take medication Enbrel, and have Pain. This study is created by eHealthMe based on reports of 48,911 people who have side effects when taking Plaquenil from Food and Drug Administration. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil knee side effects Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects., Plaquenil Hydroxychloroquine - Side Effects, Dosage. What is another name for plaquenilCyclophosphamide and hydroxychloroquine side effects Comment Plaquenil is the devil! Worked well 1st 2 mts. After that I had issues with my vision, felt waves of nervousness, and extreme anxiety where I started to question my sanity. Hallucinated, broke out in rashes and crying spells. Plaquenil oral Reviews and User Ratings Effectiveness, Ease.. Plaquenil and Knee joint replacement by duration, gender.. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Hydroxychloroquine typically is very well tolerated. Serious side effects are rare. The most common side effects are nausea and diarrhea, which often improve with time. Less common side effects include rash, changes in skin pigment such as darkening or dark spots, hair changes, and muscle weakness. But you can’t even compare it to the only other things I have to treat lupus—prednisone, where 100 percent of people get side effects, or immunosuppressive drugs, which suppress the immune system, potentially causing infections, low blood counts, and liver toxicity. Common side effects linked to Plaquenil include nausea and diarrhea. Taking the medication with food eases nausea for most people taking the drug. Less common side effects include skin rashes, hair thinning, and weakness.