Most importantly, you help support continued development of this site. The majority of cases of retinotoxicity have occurred in patients that have had a cumulative dose exceeding 1000g of hydroxychloriquine (Plaquenil). This level is reached in about 7 years with the most common daily dose of Plaquenil, 400 mg/day (200 bid). Chloroquine glioblastoma Chloroquine sp combination Chloroquine hypnozoites Chloroquine interfere nucleic acid biosynthesis Plaquenil hydroxychloroquine used for lupus and rheumatoid arthritis can cause toxicity to the retina leading to vision loss. In this episode of A State of Sight, Isaac Porter, MD explains how. For women, start with 100 pounds, and add 5 pounds for every inch over 5 feet. For men, start with 106 pounds, and add 6 pounds for every inch over 5 feet. The maximum dose of Plaquenil is 6.5 mg/kg of ideal body weight per day, regardless of whether a person is overweight, underweight, or normal weight. MONITORING FOR PLAQUINIL-INDUCED RETINAL TOXICITY Plaquenil is used for the treatment of malaria, systemic lupus erythematosus, rheumatoid arthritis, and other inflammatory and connective tissue diseases. Retinal toxicity from Plaquenil is of serious concern because even after cessation It now solely uses real body weight (rather than ideal body weight) based on new recommendations from a 2014 study (1). Disclaimer: This tool is designed to help eye care professionals better understand the risk the of retinotoxicity from hydroxychloroquine. Please note: This calculator was modified in 9/2015. Eye test for plaquenil toxicity frequency Plaquenil Updates eyeupdate, Protecting your eyesight when taking Plaquenil Lupus. Salisbury nc opthamologist plaquenil examsHydroxychloroquine and live vaccines At a screening for retinal toxicity due to Plaquenil intake, the ophthalmologist will do a complete eye exam including dilation of the pupils to look at the inner layers of the eye. Focus on Eyes Long-term Plaquenil intake can affect your vision. MONITORING FOR PLAQUINIL-INDUCED RETINAL TOXICITY. Stonewire Optometry-Blog-Hydroxychloroquine Why you need an eye exam. Dosage for Plaquenil. The adult dose of Plaquenil to suppress malaria is 400 mg on the same day each week. The pediatric weekly suppressive dosage is 5 mg/kg of body weight. The adult dose of Plaquenil to treat an acute attack of malaria is an initial dose of 800 mg followed by 400 mg in six to eight hours and 400 mg for two more days. Multifocal electroretinography mfERG may be the most sensitive test for early toxicity, although it may not be readily available in all locations. The new guidelines recommend 10-2 automated perimetry, plus at least one of SD-OCT, FAF, or mfERG if they are available. Diagnosis was delayed because visual field testing, the most sensitive test for 4‐aminoquinoline–associated retinopathy, was not done when the patient reported her symptoms to her ophthalmologist. Screening for HCQ‐associated macular toxicity remains nonuniform with respect to tests performed and frequency of testing.