This stands for Disease-Modifying Anti-Rheumatic Drugs. Wait until the next scheduled time, and take your usual dose. Plaquenil tries to quiet or slow down the immune system. If you miss a dose of Plaquenil, do not make it up or double your next dose. Special eye exams for people on plaquenil Hydroxyzine chloroquine Eye side effects of plaquenil Symptoms can start to improve in one to two months, but it may take up to six months before the full benefits of this medication are experienced. Plaquenil’s long half-life in the body can cause irreversible and progressive damage, Dr. Fung said. Similarly, one study reported that 16 women who’d taken hydroxychloroquine or chloroquine, or a combination of the agents, showed no improvement seven years after stopping drug therapy, and progression occurred in six of the cases. 2 What Are Side Effects of Plaquenil? Common side effects of Plaquenil include. nausea, vomiting, stomach pain or cramps, loss of appetite, weight loss, diarrhea, dizziness, spinning sensation, headache, ringing in your ears, mood changes, nervousness, irritability, skin rash, itching, or; hair loss. Tell your doctor if you experience serious side effects of Plaquenil including. muscle weakness, twitching, Plaquenil changes the way your immune system works. Plaquenil relieves pain and swelling and prevents damage to joints. In some kinds of lupus, your immune system attacks your body instead of protecting it. Your body weight will tell your doctor what dose is safe for you. How long to see effects of plaquenil Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus, Rx Side Effects New Plaquenil Guidelines and More - American. What is chloroquine phosphatePlaquenil side effects fatigueLupus medication hydroxychloroquine side effects Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis, prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Today, it is used to treat rheumatoid PATIENT FACT SHEET Hydroxychloroquine Plaquenil. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Protecting your eyesight when taking Plaquenil Lupus.. Plaquenil is taken by mouth with food or milk to prevent stomach problems. When taking this medication, some patients may experience upset stomach, nausea, loss of appetite, headaches or dizziness. Sometimes, taking high doses or long-term treatment of Plaquenil can lead to vision problems. Serious Side Effects of Plaquenil If you are taking Plaquenil long-term, such as for an autoimmune condition, your doctor should regularly check you for potential serious side effects. Download PDF. Drug-induced ocular side effects are back in the spotlight, thanks to the Academy’s revision of its recommendations on screening for retinal toxicity from chloroquine and its analogue hydroxychloroquine Plaquenil. 1 There are hundreds of drugs with potential retinal toxicity—so many that the National Registry of Drug-Induced Ocular Side Effects doesn’t stratify them by.