She had been taking hydroxychloroquine as a disease-modifying agent for about 15 years. A transthoracic echocardiogram showed reduced left ventricular function with an ejection fraction of 35% (A, Online Video 1). Aralen ancestral tomb Conditions that plaquenil treats Plaquenil and Cardiomyopathy - from FDA reports Summary Cardiomyopathy is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 10+ years, also take medication Lasix, and have Multiple myeloma. Hydroxychloroquine- or chloroquine -induced cardiomyopathy is a rare but potentially fatal condition. Hydroxychloroquine and chloroquine are often used for long-term treatment of rheumatic. Soong TR, Barouch LA, Champion HC et al 2007 New clinical and ultrastructural findings in hydroxychloroquine-induced cardiomyopathy—a report of 2 cases. Periodic-acid Schiff staining showed glycogen deposition in myocyte cytoplasm. Subsequent coronary angiography revealed normal coronary arteries. Hematoxylin and eosin staining revealed myocyte vacuolization (B). Plaquenil induced cardiomyopathy Hydroxychloroquine Induced Cardiotoxicity A Rare., PDF Hydroxychloroquine-Induced Cardiomyopathy A Case Report Hydroxychloroquine 200 mg ingredients On the basis of these classic findings, a diagnosis of hydroxychloroquine cardiomyopathy was made, and the drug was discontinued. Three months later her symptoms had completely resolved. Repeat imaging using cardiac magnetic resonance demonstrated an ejection fraction of 65% D, Online Video 2. Hydroxychloroquine A Treatable Cause of Cardiomyopathy JACC Journal.. Hydroxychloroquine-induced cardiomyopathy in a patient with.. Hydroxychloroquine-Induced Cardiomyopathy Case Report, Pathophysiology.. Genetic predisposition for HCQ‐induced cardiomyopathy was first proposed in a set of twin sisters who both suffered from SLE. 9 Chatre et al. described a case of a 61‐year‐old woman whose diagnosis of α‐galactosidase A deficiency was unmasked by chronic HCQ treatment. 10 Because Fabry disease and other lysosomal storage disorders, such. Clinical manifestations of antimalarial-induced cardiotoxicity can manifest as restrictive cardiomyopathy, dilated cardiomyopathy, or conduction abnormalities such as bundle branch and atrioventricular block. Patients usually present with HF symptoms. However, non-specific chest discomfort may be a presenting or coexisting feature. New clinical and ultrastructural findings in hydroxychloroquine-induced cardiomyopathy a report of 2 cases. Hum Pathol. 2007; 58–1863.