I remember the crushing fatigue and hope that I never have to feel that way again. I was on Plaquenil for over a year with my Limited Systemic Sclerosis and didn't notice any effect, scleroderma still progressing. :( Next week I am going to consult with my scleroderma doc what next. It's generally prescribed as a disease-modifier, in other words, to decrease pain, decrease swelling, and prevent joint damage and disability. I remained on that dosage for the first five years. You have to have you eyes checked on a very regular basis as it can cause visual changes and difficulty. Chloroquine 250 mg tablet How plaquenil works Hydroxychloroquine malaria Hydroxychloroquine generic round pill Adults—At first, 400 to 600 milligrams mg taken as a single dose or in two divided doses once a day. Then, 200 to 400 mg taken as a single dose or in two divided doses once a day. Your doctor may adjust your dose if needed. However, dose is usually not more than 600 mg or 6.5 mg per kilogram kg of body weight per day, whichever is lower. I take methotrexate injections weekly along with antibotic thereaphy of 200 mg of minocycline. Last week my doc added plaquenil to the mix. I have a pharmacist friend that says it can take up to a year to work, but once its kicks in it can be really good. For the treatment of systemic lupus erythematosus, patients should take 200 mg to 400 mg of hydroxychloroquine per day as one dose or divided into two separate doses. 1, 2 The recommended hydroxychloroquine dosage for rheumatoid arthritis is 400 mg to 600 mg a day by mouth as a single dose or divided into two separate doses. But it had an almost immediate effect for me with respect to fatigue, which I attribute to it's effect on vitamin D regulation (or dysregulation in my case). There have been times when I've stopped taking it over the years and have noticed no change in my fatigue or pain levels. The swelling/tendonitis in my fingers & toes stopped progressing after about 3 months, but 9 months later, they are still somewhat stiff and swollen, so it's difficult to know what would have happened without it. After that I was dropped to 200 mg two times a day. It's been a long time since I began taking it, but I don't remember any increase in energy. 200 mg of plaquenil how long to work Hydroxychloroquine Side Effects, Dosage, Uses, and More, How long did Plaquenil/Hydroxychloroquine take? DailyStrength Plaquenil ophthalmology guidelinesPlaquenil and dry lips How long does it take for plaquenil to work? I just started about 6 weeks ago, the rheum said it can take up to a year. I'm on a low dose- 200 mg/day, but see Dr end of this month. I'm thinking either Plaquenil will be upped and/or my Predisone. But the higher the steroid, the more trouble I have with diabetes and high blood pressure. Both. Plaquenil - does it take long time to work? - Lupus - Inspire. Hydroxychloroquine Plaquenil Success, Reviews and Side Effects. Lupus Medicines Hydroxychloroquine - Brigham and Women's.. Recently diagnosed with lupus and started 5mg prednisone and 200 mg plaquenil hydroxychloroquine twice a day. H more Recently diagnosed with lupus and started 5mg prednisone and 200 mg plaquenil hydroxychloroquine twice a day. To 5’ 6 1/2” - up to 300 mg Plaquenil daily; 5’ or shorter - up to 200 mg Plaquenil daily; Women with lupus who are AT OR BELOW their ideal body weight should go by these dosing rules 135 lbs. or more, any height - up to 400 mg Plaquenil daily; 102 lbs. to 134 lbs. - up to 300 mg Plaquenil daily Re Plaquenil - Can It Work Quickly? I tried to get on Plaquenil years ago, and couldn't tolerate it, but now I'm thinking there might be a lessor dose I should try. I'm new to the area, so don't have a rheumy yet.