It is the most common titrimetric procedure used in pharmacopoeial assays and serves a double purpose: it is suitable for the titration of very weak acids and very weak bases, and it provides a solvent in which organic compounds are soluble. The most commonly used procedure is the titration of organic bases with perchloric acid in anhydrous acetic acid. Abbreviation for hydroxychloroquine Chloroquine solubility in water Hydroxychloroquine hair growth Plaquenil westport ct visual field Thus the choice of the appropriate medium and titrant permits the determination of a variety of such materials by non-aqueous titration. Further, depending upon which part of a compound is physiologically active, it is often possible to titrate that part by proper selection of solvent and titrant. Non-aqueous titrations are widely used in the Pharmacopoeias for the assay of many drug substances based on the properties of the drug which is either weakly acidic or weak bases 7. ASSAY BY NON-AQUEOUS TITRATIONS • Acidimetry in Non-aqueous Titrations—It can be further sub-divided into two heads, namely i Titration of primary, secondary and tertiary amines, and ii Titration of halogen acid salts of bases. • Alkalimetry in Non-aqueous Titrations— titration of acidic substances 6. The Karl Fischer titration for water content is another nonaqueous titration, usually done in methanol or sometimes in ethanol. These assays sometimes take some perfecting in terms of being able to judge the endpoint precisely. Assay of chloroquine by non aqueous titration Uncertainty evaluation in the chloroquine phosphate., Non-Aqueous Titrimetric Assay for Determination of. Hydroxychloroquine fda package insertPrecaution of chloroquineIs chloroquine related to malaroneChloroquine mnemonic The method consisted of the titration of the aqueous solution of the tablet containing LNP with 0.1M NaOH potentiometrically and requires fairly large quauntities of LNP for each titration. The present manuscript describes four sensitive titrimetric methods for the determination of LNP in both pure form and in tablet form. Titrimetric assay of lisinopril in aqueous and non-aqueous.. Non aqueous titration -. Titrations - Ministry of Public Health. Reported for the assay of CQP in dosage forms. An acid-base titrimetric method was developed, where the drug was titrated with 0.1 M NaOH in MeCN H2O medium using thymol blue as indicator 4. A non-aqueous titrimetric method involoving conductometric titration of drug with HClO 4 has also been reported 5. Gravimetric Non-Aqueous Titrimetric Assay for Determination of Loratadine in Pharmaceutical Preparations. Non-aqueous titrations is the most titrimetric procedure used in pharmacopoeial assays and serves a double purpose, as it suitable for the titration of weak acids and bases and provides a solvent in which organic compounds are soluble. The nonaqueous titrimetric method was applied as parallel validation estimation. This involves volumetric determination of the chloroquine in non- aqueous solvent using 0.1M perchloric acid and crystal violet as indicator.