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    Malaria is transmitted by mosquitoes that usually bite from dusk to dawn. There is no malaria in: Malaria is a potential problem in almost all areas outside the main metropolitan centers in Indonesia. Symptoms can develop as early as six days or as late as several months after exposure. It is more effective and healthier to rely more on anti-mosquito measures than on anti-parasite drugs. Early malaria symptoms are flu like, such as head/body aches and generally feeling tired and unwell. Be aware of these points: Personal protective measures can greatly reduce the risk of being bitten by the anopheles mosquito. Untreated, it can cause complications including anaemia, seizures, mental confusion, kidney failure and coma. Because of its night time feeding habits, malaria transmission occurs primarily between dawn & dusk. Correct use of mosquito netting will greatly reduce the incidence of bites. For added protection of up to 3 months or longer, netting can be soaked in a 1% solution of permethrin or other repellent/insecticide. If staying in a malarious area, curtains should be treated in a similar manner. Mosquito coils (obat anti nyamuk) and "knockdown spray" containing pyrethroids should be used in cool dark places where mosquitoes lurk. Avoid use of dark-colored clothing, perfumes and colognes in the evening and at night. An effective mosquito repellent should be used on exposed skin and clothing. DEET () is an effective safe component of good repellents. Pyrimethamine is also used in combination with sulfadiazine to treat active toxoplasmosis. The two drugs bind the same enzymatic targets as the drugs trimethoprim and sulfamethoxazole - dihydrofolate reductase and dihydropteroate synthase, respectively. Pyrimethamine has also been used in several trials to treat retinochoroiditis. Due to the emergence of pyrimethamine-resistant strains of P. falciparum, pyrimethamine alone is seldom used now. In combination with a long-acting sulfonamide such as sulfadiazine, it was widely used, such as in Fansidar, though resistance to this combination is increasing. Synthesis of pyrimethamine typically begins with p-chlorophenylacetonitrile, which undergoes a condensation reaction with ethyl propionate ester; the product of this then reacts with diazomethane to form an enol ether, which reacts with free guanidine in a second condensation reaction.

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