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    Doxylamine is found in over-the-counter products such as Unisom and Nyquil. It may be taken to treat insomnia, but is this the best treatment option for this condition? Like the related medication diphenhydramine, doxylamine does not require a prescription. What should you consider before using this medication, and what alternative sleeping pills may work better? Learn about the use of doxylamine in treating insomnia. Doxylamine may be helpful for treating allergies, but a side effect is that it causes drowsiness. Some people will, therefore, take it to help with symptoms of insomnia, a difficulty falling or staying asleep. It can be used by itself as a short-term sedative and in combination with other drugs to provide night-time allergy and cold relief. Doxylamine is also used in combination with the analgesics paracetamol (acetaminophen) and codeine as an analgesic/calmative preparation, and is prescribed in combination with vitamin B Doxylamine succinate is a potent anticholinergic and has a side-effect profile common to such drugs, including dry mouth, ataxia, urinary retention, drowsiness, memory problems, inability to concentrate, hallucinations, psychosis, and a marked increased sensitivity to external stimuli. Like many hypnotics, it should not be combined with other antihistamines, such as cetirizine (Zyrtec) or diphenhydramine (Benadryl), as this combination can increase the risk of serious side effects. Using doxylamine over a long period of time is not recommended. However, the drug is not addictive, and withdrawal effects are unlikely to be experienced with prolonged use. Because of its relatively long elimination half-life (10–12 hours), doxylamine is associated with daytime/next-day drowsiness, grogginess, dry mouth, and tiredness when used as a hypnotic. Fatalities have been reported from doxylamine overdose.

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