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    We use cookies to make interactions with our website easy and meaningful, to better understand the use of our services, and to tailor advertising. For further information, including about cookie settings, please read our Cookie Policy . By continuing to use this site, you consent to the use of cookies. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Methods: A randomized, double-blind, placebo-controlled pilot study took place in 10 patients with secondary RP. Listing a study does not mean it has been evaluated by the U. Topical 10% nifedipine on one hand and 5% sildenafil on the other hand were applied. Objective: To compare the efficacy of topical 10% nifedipine versus 5% sildenafil in patients with secondary Raynaud's phenomenon (RP). The thumbs didn't receive any cream and served as a control group. The primary outcome was the improvement of blood flow and vessel diameter of the digital arteries measured by high frequency color Doppler ultrasound before and 1 hour after treatment. Patient hands (right versus left) were randomized to treatment with topical sildenafil or nifedipine cream. The thumbs of both hands didn't receive any cream so that each subject served as her own control.

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