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    Sildenafil Sildenafil is a vasoactive agent used to treat erectile dysfunction and reduce symptoms in patients with pulmonary arterial hypertension (PAH). Sildenafil elevates levels of the second messenger, c GMP, by inhibiting its breakdown via phosphodiesterase type 5 (PDE5). PDE5 is found in particularly high concentrations in the corpus cavernosum, erectile tissue of the penis. It is also found in the retina and vascular endothelium. Increased c GMP results in vasodilation which facilitates generation and maintenance of an erection. The vasodilatory effects of sildenafil also help reduce symptoms of PAH. Sildenafil Citrate, more commonly known as Viagra, is a drug that is used to treat erectile dysfunction and pulmonary arterial hypertension (PAH). The main function of the drug is to inhibit the enzyme that degrades c GMP, a regulator of blood flow to the penis. The medical uses for Sildenafil Citrate are sexual dysfunction, pulmonary hypertension, and altitude sickness. In 1998, the drug Viagra was introduce as an effective way to treat male erectile dysfunction (MED). It has quickly become one of the most popular and most prescribed drugs in the world. Its annual sales account for over a billion dollars each year. Sildenafil was synthesized by a group of pharmaceutical chemists working at Pfizer’s research facility in England. It was discovered by accident while attempting to produce a drug to treat coronary heart disease.

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