Like a lot of young women, I've been on and off of antidepressants for my entire adult life. I started taking them at 18 because I was having an extremely phobic OCD episode; a response to my parents getting divorced, the prospect of going off to college, and getting head lice, all in the same year. I suffered from a constant, plaguing paranoia that I still had bugs in my hair. I developed countless compulsions to keep myself safe from infecting others and even from reinfecting myself. The only time I wasn't thinking about bugs was when I was having particularly exciting sex with my summer fling, the only person I allowed my hair to touch. After I had a severe panic attack in a thrift store and ended up curled up in the trunk of my mom's car, I admitted that I couldn't take it anymore. I thrived on the medication, and could sleep soundly for the first time in my life. My therapist recommended a small dose of Lexapro, a serotonin reuptake inhibitor (SSRI) known for treating anxiety. By 2008, SSRIs were already the most popular medication in America, with 11 percent of the adult population taking one. On SSRIs, my compulsive thoughts and behaviors subsided enough that I was able to go off to college, continue therapy to address my OCD and anxiety, and even fall in love again. In fact, I was pleasantly sort-of-tired all the time. tamoxifen increase testosterone All antidepressant drugs are not created equal, according to the authors of one of the few studies that have ever systematically analyzed and compared "new generation" medicines for treating depression. In the analysis of 12 drugs, two came out on top as the most effective and best tolerated as first-line treatments: sertraline (Zoloft) and escitalopram (Lexapro). Venlafaxine (Effexor) and mirtazapine (Remeron) rounded out the top four for effectiveness, but venlafaxine was also among the four drugs patients were most likely to quit taking because of side effects. H., who coauthored a review of the benefits and risks of the same 12 drugs published last November in the Annals of Internal Medicine. Reboxetine (Edronax) was less effective than the rest. Parikh, who wrote a comment accompanying the study that is published in the current issue of The Lancet, says the findings have "enormous implications" because, for the first time, they offer doctors an evidence-based, unbiased way to recommend treatment. He and his colleagues concluded, based on their review done while Gartlehner was at the RTI-UNC Evidence-Based Practice Center in Chapel Hill, North Carolina., that there was no clinically meaningful evidence that any one of the drugs was better than the rest. While psychiatrists treating depressed patients every day have had a sense of which medications are best, the current study "nails it," says Sagar V. And, he adds, they give patients a "gold standard of reliable information," especially since the study's authors plan to make their findings available free on the Web. Instead, they argued, decisions on which drug to use should be based on factors such as cost and side effects. D., of the University of Verona in Italy, and colleagues used a new technique called multiple-treatments meta-analysis to make head-to-head comparisons among the 12 drugs, incorporating 117 randomized controlled trials including 25,928 patients in all. There has been little scientific evidence of the relative effectiveness of these drugs, because most studies compare one against a handful of others or a placebo, and are often funded by the maker of a particular drug, which can bias the findings in its favor, the researchers note. Health.com: How to brighten your winter mood They used two measurements to gauge a drug's effectiveness and tolerability: the percentage of patients who showed at least a 50 percent improvement in their symptoms as measured by one of two scales, or who scored "much improved or very much improved" after eight weeks of treatment (or from six to twelve weeks if eight-week data weren't available) and the percentage of patients who dropped out of the study before eight weeks for any reason. Metformin weight gain Metformin vs cinnamon Buy cheap doxycycline in usa Feb 2, 2009. Is one antidepressant more effective than another? A new summary of "horse race" studies favors Zoloft and Lexapro -- but the real winner is. azithromycin ophthalmic solution generic Dec 14, 2017. Lexapro escitalopram and Zoloft sertraline are selective serotonin reuptake inhibitor SSRI type antidepressants used to treat depression. Data from placebo-controlled and/or head-to-head comparisons of the ASRI escitalopram versus the SSRIs sertraline and paroxetine are listed in Table 1 and. .pass_color_to_child_links a.u-margin-left--xs.u-margin-right--sm.u-padding-left--xs.u-padding-right--xs.u-absolute.u-absolute--center.u-width--100.u-flex-align-self--center.u-flex-justify--between.u-serif-font-main--regular.js-wf-loaded .u-serif-font-main--regular.amp-page .u-serif-font-main--regular.u-border-radius--ellipse.u-hover-bg--black-transparent.u-hover-bg--black-transparent:hover. Content Header .feed_item_answer_user.js-wf-loaded . Lexapro (escitalopram) and Zoloft (sertraline) are medications of the selective-serotonin reuptake inhibitor (SSRI) classification utilized most commonly for the management of major depressive disorder (MDD). Zoloft was developed by the pharmaceutical company Pfizer Inc. By scanning the chart, it should be easy to pinpoint the obvious similarities and differences between these medications. Interacts with the serotonin transporter (SERT) to prevent reabsorption of serotonin into the presynaptic neuron. Lexapro was co-developed by the pharmaceutical companies Lundbeck and Forest Laboratories (starting in 1997) and received U. Additional (less significant) actions: -Dopamine reuptake inhibitor -Increases extracellular norepinephrine -Sigma-1 receptor antagonist: This chart may be subject to inaccuracies and/or outdated information. Included below is a chart highlighting general attributes of Lexapro (escitalopram) and Zoloft (sertraline). Both Lexapro and Zoloft function by modulating concentrations of serotonin (5-HT) within the brain to generate antidepressant and anxiolytic effects. If you ever have any specific questions about the attributes of Lexapro and/or Zoloft – it is recommended to contact a medical doctor or pharmacist. Noteworthy differences between Lexapro and Zoloft include: official medical uses; off-label uses; bioavailability, metabolism specifics; elimination half-life; date of release; and incidence of specific side effects. Though both Lexapro and Zoloft are officially approved to treat major depressive disorder (MDD), only Lexapro is medically indicated for the treatment of generalized anxiety disorder (GAD). FDA) to treat a greater number of medical conditions than Lexapro. Zoloft vs cipralex What A Decade On SSRIs Forced Me To Confront - Bustle, Lexapro vs. Zoloft for Depression and Anxiety Differences & Side Effects Buy lasix online cheap Purchase acyclovir canada Cialis trial Lasix 60 Dec 10, 2003. A clinical study showed that Lexapro TM is as effective and well tolerated as Zoloft®. The purpose of the study was to evaluate the efficacy of. Starting dose of Lexapro™ as effective as optimally dosed Zoloft® in. A comparative review of escitalopram, paroxetine, and sertraline are. Lexapro vs Zoloft What is Zoloft - October 2012 Bolinas. Nov 2, 2017. Zoloft sertraline and Lexapro escitalopram are antidepressant drugs in the selective serotonin reuptake inhibitor SSRI class used for. sertraline dosage for anxiety Oct 29, 2018. Lexapro and Zoloft are both commonly prescribed for depression and anxiety. While similar, both drugs have their differences that we compare. Aug 23, 2016. With all the different depression and anxiety medications on the market, it can be hard to know which drug is which. Lexapro and Zoloft are two.